A synthesis of 5-amino- and 5-hydroxy-l-ethyl-1,4-dihydrio-4-oxo-3-quinolinecarboxylic acids and their derivatives |
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Authors: | Yasumitsu Tamura Masanobu Fujita Ling Ching Chen Kyoji Ueno Yasuyuki Kita |
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Abstract: | The synthesis and antimicrobial activity of 5-Hydroxy-l-ethyl-1,4-dihydrio-4-oxo-3-quinolinecarboxylic acids and their derivatives have been investigated. The 5-hydroxy-3-quinolinecarboxylic acids were prepared by thermal cyclization of 3-oxocyclohexenylaminomethylenemalonates followed by aromatiza-tion with iodine-ethanol, ethylation and hydrolysis of products. The 5-amino derivatives were prepared by several steps involving novel aromatization of isoxazole intermediates. |
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