Conformational study of anticholinesterase carbamates in the furylbenzene series by 1H and 13C NMR spectroscopy

The structural analysis of carbamates derived from 2-(α-furyl)benzaldoximes and 2-(α-furyl)benzyl alcohols was carried out by ¹H and ¹³C NMR spectroscopy. The conjugative and steric effects of alkyl substituents introduced on the benzene rings were found to modify the relative orientation of the aromatic and furan rings. The existence of a close relationship between the stereochemistry of the studied compounds and their anticholinesterase activity has been proposed.