A novel synthesis of arylpyrrolo[1,2-a]pyrazinone derivatives |
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Authors: | Wang Fei Wang Jiawei Zhang Shoufang |
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Institution: | School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, PR China. wfei77502@sina.com |
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Abstract: | Some aryl-2-methyl-1-pyrrolo1,2-a]pyrazinones were designed and prepared to study the Structure-Activity Relationships (SAR) of pyrrolo1,2-a]pyrazinone derivatives. With methyl pyrrole-2-carboxylate as the starting material, the title compounds were prepared through N-alkylation and two novel cyclizations. Eleven aryl-2-methyl-1- pyrrolo1,2-a]pyrazinone derivatives not previously reported in the literature are presented in this paper. Some of them show potent anti-inflammatory and analgesic activities. |
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