Synthesis of 3-cyano-5-ethoxycarbonyl-4-isobutyl-6-methyl-3,4-dihydropyridine-2(1H)-thione by three-component condensation |
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| Authors: | S. G. Krivokolysko V. D. Dyachenko V. P. Litvinov |
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| Affiliation: | (1) T. G. Shevchenko State Pedagogical Institute, 2 ul. Oboronnaya, 348011 Lugansk, the Ukraine;(2) N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 117913 Moscow, Russian Federation |
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| Abstract: | Condensation of isovaleraldehyde with cyanothioacetamide and ethyl acetoacetate (or its enamine) gives 3-cyano-5-ethoxycarbonyl-4-isobutyl-6-methyl-3,4-dihydropyridine-2(1H)-thione. This compound was used in the synthesis of substituted 1,4-dihydropyridin-2-yl sulfides. Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 166–168, January, 1999. |
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| Keywords: | isovaleraldehyde cyanothioacetamide ethyl acetoacetate pyridine condensation |
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