首页 | 本学科首页   官方微博 | 高级检索  
     检索      


Catalysis reaction between sodium 1,2-naphthoquinone-4-sulfonate and hydroxyl ion using captopril as catalyzer and determination of captopril
Authors:Gao Linxiao  Wu Lingli  Li Quanmin
Institution:a College of Chemistry and Environmental Science, Henan Normal University, Henan Key Laboratory for Environmental Pollution Control, Xinxiang, Henan 453007, PR China
b College of Agriculture and Medicine, Henan Redio & Television University, Zhengzhou, Henan 40008, PR China
Abstract:A novel and simple spectrophotometric method for the determination of Captopril with sodium 1,2-naphthoquinone-4-sulfonate is established in this paper. The detailed reaction mechanism is proposed and discussed. It is based on the fact that captopril can catalyze the reaction between sodium 1,2-naphthoquinone-4-sulfonate and hydroxyl ion to form 2-hydroxy-1,4-naphthoquinone in buffer solution of pH 13.00. Beer's law is obeyed in a range of 0.64-80 μg mL−1 at the maximal absorption wavelength of 442 nm. The equation of linear regression is A = 0.05815 + 0.00589C (μg mL−1), with a linear regression correlation coefficient of 0.9981. The detection limit is 0.3 μg mL−1, R.S.D. is 0.77% and the recovery rate is in range of 96.0-103.8%. Furthermore, the method has been validated and successfully applied to the determination of captopril in pharmaceutical samples.
Keywords:Captopril  Sodium 1  2-naphthoquinone-4-sulfonate  Spectrophotometry  Catalytic reaction
本文献已被 ScienceDirect PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号