A selective colorimetric chemosensor for thiols based on intramolecular charge transfer mechanism |
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| Authors: | Zeng Yan Zhang Guanxin Zhang Deqing |
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| Affiliation: | a Beijing National Laboratory for Molecular Sciences, Organic Solids Laboratory, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China
b Graduate School of Chinese Academy of Sciences, Beijing 100080, China |
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| Abstract: | Compound 1 as an electron donor-acceptor compound with N,N-dimethylaniline and quinone units was designed for a highly selective colorimetric determination of thiol-containing amino acids and peptides, by making use of the unique reactivity of thiol towards quinone. Compound 1 shows a strong intramolecular charge transfer (ICT) band around 582 nm; but, it decreased after addition of either cysteine (Cys) or glutathione (GSH). Moreover, the ICT band intensity at 582 nm decreased linearly with the increasing concentrations of Cys or GSH. The interference from other amino acids can be neglected. Therefore, compound 1 can be employed as a selective colorimetric visual chemosensor for thiol-containing amino acids and peptides. |
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| Keywords: | Intramolecular charge transfer Electron donor-acceptor compound Michael reaction Cysteine Glutathione |
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