Generation, basic chemistry, and detection of N-nitrosotryptophan derivatives |
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Authors: | Kirsch Michael Korth Hans-Gert |
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Affiliation: | Institut für Physiologische Chemie, Universit?tsklinikum Essen, Hufelandstrasse 55, 45122 Essen, Germany. michael.kirsch@uni-duisburg-essen.de |
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Abstract: | N-Terminal blocked tryptophan derivatives like melatonin or tryptophan residues in peptides are easily nitrosated at the nitrogen atom of the indole ring to give the corresponding N-nitrosotryptophan derivatives. This article provides a comprehensive view of the synthesis, chemical properties, and detection methods of this class of N-nitroso compounds of potential importance in biological systems. |
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