Catalytic asymmetric C-H insertions of rhodium(II) azavinyl carbenes |
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| Authors: | Chuprakov Stepan Malik Jamal A Zibinsky Mikhail Fokin Valery V |
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| Institution: | The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. |
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| Abstract: | A highly efficient enantioselective C-H insertion of azavinyl carbenes into unactivated alkanes has been developed. These transition metal carbenes are directly generated from readily available and stable 1-sulfonyl-1,2,3-triazoles in the presence of chiral Rh(II) carboxylates and are used for C-H functionalization of alkanes to access a variety of β-chiral sulfonamides. |
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