Crystallographic evidence of an unusual, pentagon-shaped folding pattern in a circular aromatic pentamer |
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Authors: | Qin Bo Chen Xiuying Fang Xiao Shu Yingying Yip Yeow Kwan Yan Yan Pan Siyan Ong Wei Qiang Ren Changliang Su Haibin Zeng Huaqiang |
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Institution: | Department of Chemistry and NUS MedChem Program of the Office of Life Sciences, National University of Singapore, Singapore. |
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Abstract: | Introduction of a continuous hydrogen-bonding network suppressed the conformational flexibility of an oligomeric backbone. Cyclization of a rigidified, suitably sized oligomer led to a circular aromatic pentamer. Its crystal structure determined by X-ray crystallography reveals a pseudo five-fold symmetric planarity in the solid state, which is quite unusual among all the previously described shape-persistent macrocycles and synthetic foldamers with biased conformations enforced by noncovalent forces. |
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