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Assessment of analytical testing: The impact of metrics for the sustainable measurement of pharmaceuticals
Affiliation:1. Analytical Research & Development, Merck & Co. Inc., Rahway, NJ, USA;2. Analytical Research & Development, MSD., WAG, Wethenstein, LU, Switzerland;3. Tango Therapeutics, 201 Brookline Ave, Suite 901, Boston, MA, USA
Abstract:Analytical metrics allow a periodic, healthy examination of methods and how they impact the environment, while ensuring that procedures are reproducible, reliable, repeatable, transferable, and of high quality. This article provides a review of current trends with analytical metrics, such as the analytical method green score (AMGS). More importantly, the AMGS impact on sample preparation, development strategy, and energy consumption considerations are provided. Finally, recent uses of metrics with specific relevance to the pharmaceutical research and development area through method transfer are covered.
Keywords:Analytical metrics  Method greenness  Sustainable development
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