One-Pot Synthesis of 3-(Trimethylsilyl)propynamides |
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| Authors: | A. S. Medvedeva M. V. Andreev L. P. Safronova |
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| Affiliation: | 1.Favorskii Irkutsk Institute of Chemistry Siberian Division,Russian Academy of Sciences,Irkutsk,Russia |
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| Abstract: | A highly efficient one-pot procedure was developed for the synthesis of 3-trimethylsilylpropynamides by acylation of amines with trimethylsilylpropynoyl chloride generated in situ. Selective N-acylation and N,O-bis-acylation of ß-amino alcohols with formation of, respectively, N-(hydroxyalkyl)propynamides and 2-methyl-2-[3-(trimethylsilyl)propynoylamino]propyl 3-(trimethylsilyl)propynoate were accomplished with high yields. |
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