Daphmanidins C and D, novel pentacyclic alkaloids from Daphniphyllum teijsmanii |
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| Authors: | Morita Hiroshi Ishioka Nozomi Takatsu Hiroshi Shinzato Takakazu Obara Yutaro Nakahata Norimichi Kobayashi Jun'ichi |
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| Institution: | Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. |
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| Abstract: | structure: see text] Two novel alkaloids with an unprecedented fused-pentacyclic skeleton, daphmanidins C (1) and D (2), have been isolated from the leaves of Daphniphyllum teijsmanii, and the structures were elucidated on the basis of spectroscopic data. The relative stereochemistry of 1 and 2 was assigned by combination of NOESY correlations and a simulation analysis. Daphmanidin C (1) elevated activity of NGF biosynthesis. |
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