Peculiarities of inclusion complex formation in the 1,4-benzodiazepine-benzene system |
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| Authors: | J Lipkowski K S Andronati Yu A Simonov V Ch Kravtsov |
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| Institution: | 1.Institute of Physical Chemistry,Polish Academy of Sciences,Warsaw,Poland;2.A. V. Bogatsky Physico-Chemical Institute of the National Academy of Sciences,Ukraine;3.Institute of Applied Physics,Academy of Sciences of Moldova,Moldova |
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| Abstract: | 5-Phenyl-1-methyl-7-bromo-3-hydroxy-1,2-dihydro-3H-1,4-benzodiazepin-2-one and its 5-(o-chloro)-phenyl analog form 2:1 (host:guest) inclusion compounds with benzene. The crystal structures of the compounds were studied by the single-crystal XRD method and were interpreted as host (H) (benzodiazepine) — guest (G) (benzene solvent molecule) complexes. The studied structures, revealing H-H and H-G interactions as both typical hydrogen bonds and π-π, C-H?π weak interactions, may serve as models for ligand-receptor binding. |
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