Cell Adhesion Micropatterning by Plasma Treatment of Alginate Coated Surfaces |
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Authors: | Morra Marco Cassinelli Clara |
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Affiliation: | (1) Nobil Bio Ricerche, Str. S. Rocco 32, 14018 Villafranca d'Asti, Italy |
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Abstract: | Air plasma treatment, coupled to a masking technique, was used to promote micropatterned cell adhesion onto a cell-adhesion-resistant alginate coated surface. L-929 mouse fibroblasts were successfully confined into 50 m diameter cell-adhesive areas patterned inside a cell-resistant layer. The plasma treatment performed, albeit very mild, destroys the molecular architecture of the hydrophilic polysaccharide coating, leading to an enhancement of protein adsorption and hence of cell-adhesion. Both the cell-adhesion-resistant and the cell-adhesive regions are hydrophilic, yet they show a completely different behavior towards cells. Thus, they are a very interesting subject in the study of interfacial interactions in aqueous media, and, in particular, on the mechanisms of bio-adhesion at hydrophilic surfaces. |
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Keywords: | Micropatterning cell adhesion wettability alginate polysaccharides surface modification plasma |
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