Middle Tennessee State University, Department of Chemistry, Murfreesboro, Tennessee 37132, USA. ndunlap@mtsu.edu
Abstract:
An efficient approach to novel cyclopropyl peptidomimetics has been developed. The synthetic route involves a cyclopropanation using ethyl (dimethylsulfuranylidene)acetate (EDSA) as the key step and affords a cyclopropyl peptidomimetic core in three steps from protected amino acid Weinreb amides.