| 电压调制型高灵敏电化学发光分析 |
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| 引用本文： | 张晶晶,金融,方丹君,江德臣.电压调制型高灵敏电化学发光分析[J].高等学校化学学报,2020,41(11):2421. |
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| 作者姓名： | 张晶晶 金融 方丹君 江德臣 |
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| 作者单位： | 1.南京医科大学药学院, 南京 211166;2.南京大学化学化工学院, 生命分析化学国家重点实验室, 南京 210023 |
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| 基金项目： | 国家自然科学基金(21974071) |
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| 摘 要： | 报道了一种电压调制型电化学发光分析技术, 通过在施加恒定电压的基础上叠加一个小脉冲电压, 可将鲁米诺-过氧化氢体系的电化学发光强度提升近2倍. 电化学发光强度与过氧化氢浓度在1.0 nmol/L~200 μmol/L范围内呈现良好的线性关系, 检出限低至0.24 nmol/L(S/N=3). 研究结果表明, 通过电压调制模式可有效提高电化学发光强度, 为深入理解电极界面电化学过程提供了新技术和数据.
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| 关 键 词： | 电化学发光 电压调制 鲁米诺 过氧化氢 高灵敏检测 |
| 收稿时间： | 2020-06-15 |
Voltage Modulated Electrochemiluminescence for Highly Sensitive Detection |
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| ZHANG Jingjing,JIN Rong,FANG Danjun,JIANG Dechen.Voltage Modulated Electrochemiluminescence for Highly Sensitive Detection[J].Chemical Research In Chinese Universities,2020,41(11):2421. |
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| Authors: | ZHANG Jingjing JIN Rong FANG Danjun JIANG Dechen |
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| Institution: | 1.School of Pharmacy，Nanjing Medical University，Nanjing 211166，China;2.State Key Laboratory of Analytical Chemistry for Life Science，School of Chemistry and Chemical Engineering，Nanjing University，Nanjing 210023，China |
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| Abstract: | A voltage modulated electrochemiluminescent（ECL） method is established for highly sensitive detection. In this new strategy， a small voltage is imposed at a constant voltage that could increase ECL intensity from luminol-hydrogen peroxide by ca. 2 times. This ECL intensity shows a good linear relationship with the concentration of hydrogen peroxide in the range of 1 nmol/L—200 μmol/L with a detection limit of 0.1 nmol/L（S/N=3）. The results exhibit that the voltage modulated ECL could be an effective way to increase ECL intensity， and more importantly， used to study the electrochemical process at the electrode interface. |
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| Keywords: | Electrochemiluminescence Voltage modulation Luminol Hydrogen peroxide Highly sensitive detection |
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