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Acylation of Quercetin with a Novel Thermophilic Esterase as Biocatalyst |
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| Authors: | XIE Xiao-na ZHANG Chun-li XUN Er-na WANG Jia-xin ZHANG Hong WANG Lei WANG Zhi |
| Institution: | 1. The First Hospital of Jilin University, Changchun 130021, P. R. China; 2. Key Laboratory for Molecular Enzymology and Engineering, Ministry of Education, Jilin University, Changchun 130012, P. R. China; 3. College of Physical Education, Jilin University, Changchun 130012, P. R. China |
| Abstract: | The regioselective acylation of quercetin catalyzed by a novel thermophilic esterase(APE1547) from the archaeon Aeropyrum pernix K1 was successfully conducted in organic solvents. The effects of acyl donor, substrate ratio, organic solvent, temperature, and water activity were investigated. Under the optimum conditions, a yield of 74% for its mono ester could be achieved in the reaction for about 6 h. With the reaction time extending to about 30 h, the final conversion of quercetin was about 100% and three products were synthesized. |
| Keywords: | Quercetin Vinyl acetate APE1547 Acylation |
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