Cyclic transformations of 5-aryl(or benzyl)-3-(2-bromoethyl- 1,3,4-oxadiazol-2(3H)-ones into 1-aminoimidazolidin-2-one and 5,6-dihydro-4H-1,3,4-oxadiazine derivatives |
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Authors: | Ren Milcent,G o Barbier |
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Affiliation: | René Milcent,Géo Barbier |
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Abstract: | 5-Aryl(or benzyl)-3-(2-bromoethyl)-1,3,4-oxadiazol-2(3H)-ones 3 have been prepared. They were reacted with secondary alkylamines without any change of the heterocycle to give amino derivatives 6 , but with primary alkylamines, cyclic transformation occurred to give 1-acylamino-3-alkylimidazolidin-2-ones 7 . In the presence of sodium alcoholate, bromo compounds 3 were transformed into 2-aryl(or benzyl)-4-alkoxycarbonyl-5,6-dihydro-4H-1,3,4-oxadiazines 9 . |
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