| Abstract: | By combination of centrifugal partition chromatography (CPC) and common separation methods, twelve known bases were isolated and characterized from the first chemical investigation of Neolitsea konishii (H.) K. & S. They belong to isoquinoline alkaloids of four types: eight aporphines, nornuciferine (1), N-methyllaurotetanine (2), laurolitsine (3), boldine (4), laurotetanine (5), isoboldine (6), actinodaphine (7) and corytuberine (8); two proaporphines, stepharine (9) and glaziovine (10); one benzylisoquinoline, reticuline (11); and one morphinan, pallidine (12). Among these, compounds 3, 6 and 11 are abundant and will be modified for pharmacological tests. The content of various alkaloids in the plant is useful as a basis for chemotaxonomy. |
