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Tritium Labelling of Cyprodime ( = (—)-17-(Cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one), a μ Receptor-Selective Opioid Antagonist |
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| Authors: | Ferenc tvs Gza Tth Helmut Schmidhammer |
| Institution: | Ferenc Ötvös,Géza Tóth,Helmut Schmidhammer |
| Abstract: | The preparation of 1-3H]cyprodime ( 2 ), which has a specific activity of 31.6 Ci/mmol was carried out by catalytic tritiodehalogenation of 1-bromocyprodime ( 3 ). Bromination of cyprodime was performed by using chloroperoxidase, KBr, and H2O2. |
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