Synthesis of quinazolino-1,3-benzothiazine derivatives |
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Authors: | Jnos Szab Ernest Bani-Akoto Gyrgy Dombi Gbor Bernth Lajos Fodor PL Sohr |
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Institution: | János Szabó,Ernest Bani-Akoto,György Dombi,Gábor Bernáth,Lajos Fodor,PÁL Sohár |
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Abstract: | The ring-closure reactions of N-(3,4-dimethoxyphenylthiomethyl)-2-nitrobenzamide derivatives 5a,b with phosphoryl chloride gave 4-(2-nitrophenyl)-2H1,3-benzothiazine derivatives 7a,b , which on reduction yielded 4-(2′-aminophenyl)-3,4-dihydro-2H-1,3-benzothiazines 8a,b. Reaction of these compounds with phosgene led to a new heterocyclic ring system, 6H,8H-quinazolino3,4-c]1,3]benzothiazine derivatives 9a,b. The structures of the title compounds were proved via their ir and nmr (1H, 13C) spectra. |
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