Synthesis of large-ring lactams by a carbene-anion bond forming reaction |
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Authors: | Eric L. Williams |
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Abstract: | Treatment of large-ring lactams 1 with potassium t-butoxide results in the formation of bicyclic structures 2 . Evidence was obtained to support the formation of 2 through a carbene-anion coupling. The structures of a series of bicyclic lactams 2 have been rigorously defined. |
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