The synthesis of a new benzothiazine derivative,related to oxicams,synthesized from natural safrole

The synthesis of the new derivatives, 2-methyl-6,7-methylenodioxy-2H-1,2-benzothiazin-3-one-4-(N-phenyl)carboxamide 1,1-dioxide ( 6a ) from natural safrole ( 5 ) is described. The principal feature of this route is brevity and the high overall yield, producing the new analogue in ca. 35% from the natural product.