A Convenient and efficient method for the preparation of 6-Acyl-2(3H)-benzoxazolones |
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Authors: | Hocine Aichaoui Daniel Lesieur Jean-Pierre Hnichart |
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Institution: | Hocine Aichaoui,Daniel Lesieur,Jean-Pierre Hénichart |
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Abstract: | Benzoxazolinone derivatives have been found to exhibit various pharmacological properties and 6-acyl-2(3H)-benzoxazolones are considered as key starting materials for the preparation of these compounds. Reported here are the optimal conditions for a regioselective acylation at the 6-position of the benzoxazolinone ring. A general method leading to the expected products in excellent yields consists in using a mixture of aluminum chloride-dimethylformamide as catalyst and acid anhydrides or chlorides as acylating agents. |
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