Control of the regiospecific synthesis of dialkylpyrrolizidinones and their stereochemical behaviour using gas chromatography/mass spectrometry with chemical ionization |
| |
Authors: | C. Lange O. Provot C. Mulheim J.-P. Celerier G. Lhommet |
| |
Abstract: | Pyrrolizidine alkaloids were synthesized via the cyclization of an epoxide prepared from a lactam. The regiospecific control of this reaction is demonstrated using gas chromatography/mass spectrometry. Ammonia chemical ionization mass spectrometry permits the determination of the cis–trans stereochemistry of the final products. |
| |
Keywords: | |
|