Reactions of Benzoyl Isothiocyanate with Active Methylene Reagents: A Novel Synthesis of Thiophene,Thiazoline and Thieno[2,3-d]Pyrimidine Derivatives |
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Authors: | Rafat Milad Mohareb Suzan Ibrahim Aziz Nadia Iskander Abdel Saved Hoda Zaki Shams |
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Abstract: | Various derivatives of thiophene, thiazoline and thienopyrimidine have been synthesized via the reaction of active methylene reagents (la-j) with benzoyl isothiocyanate in the presence of potassium hydroxide, followed by the subsequent treatment of the potassium salt intermediates 2a-j with phenacyl bromide or ethyl chloroacetate. The stability of the formed adducts 3 and 12 or their selective cyclization depends on both the nature of the active methylene reagent and the α-halocarbonyl compounds. |
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Keywords: | Isothiocyanatc Thiophenes Thiazolines Thienopyrimidines |
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