Synthesis and stereochemistry of (3α)-6β,7β-dihydroxy- and 6β-hydroxy-8-alkyl-8-azabicyclo[3.2.1]octane-3-spiro-5′-imidazoline-2′,4′-diones |
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Authors: | Mercedes Villacampa Manuel Martínez Gregorio Gonzlez-Trigo M Nica M Sllhuber |
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Institution: | Mercedes Villacampa,Manuel Martínez,Gregorio González-Trigo,Mó Nica M. Söllhuber |
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Abstract: | The synthesis of 6β-hydroxy- and 6β,7β-dihydroxy-8-alkyl-8-azabicyclo3.2.1]octane-3-spiro-5′-hydantoins was stereoselectively achieved by Bucherer-Bergs reaction of the corresponding ketones. An α configuration on C3 was proposed for all hydantoins on the basis of spectral data. |
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