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Stereospecific construction of substituted piperidines. Synthesis of (-)-paroxetine and (+)-laccarin |
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| Authors: | Bower John F Riis-Johannessen Thomas Szeto Peter Whitehead Andrew J Gallagher Timothy |
| Institution: | School of Chemistry, University of Bristol, Bristol, UKBS8 1TS. |
| Abstract: | Short and efficient enantioselective syntheses of (-)-paroxetine and (+)-laccarin are described based on the highly stereospecific cleavage of C(3)-substituted 1,3-cyclic sulfamidates. |
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