Peptides-assisted charge transfers in proteins: relay mechanism and its controllability |
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Authors: | Yuxiang Bu |
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Institution: | (1) National Center on nanoStructures and bioSystems at Surfaces of INFM-CNR, Center for NanoBiotechnology, Modena, Italy;; |
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Abstract: | This feature article addresses several novel aspects regarding the peptide-mediated charge migrations, including: i) radical
exchanges with tunable radical types (σ-radical versus π-radical) and electron-transfer (ET)-channel-tunable cooperative proton-coupled
ET (PCET) mechanism, including hydrogen-atom transfer (HAT), single ET-channel PCET, double ET channel PCET, and channel-type-tunable
(σ-channel versus π-channel) PCET; ii) hole hopping migration between the active groups in the side-chains and its controllability;
iii) hole hopping through stepping-stones via a solvated “hole” form; and iv) electron hopping through positively charged
groups as stepping-stones via a solvated electron state. In particular, the controllability of the ET channels (pathways and
types) and solvated-“hole”/“electron”-based relay mechanisms are mainly mentioned. Clearly, this is an important addition
to the well-documented mechanisms for charge migration in proteins. In view of the complexity of protein charge migration,
further exploration on details of the stepping-stone-based relay mechanisms, by considering the properties and structures
of the redox active centers, their intercalators, and the real surroundings, is still needed. |
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Keywords: | |
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