Targeting alpha-synuclein in Parkinson's disease |
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| Authors: | Kapurniotu Aphrodite |
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| Institution: | Laboratory of Bioorganic and Medicinal Chemistry, Institute of Biochemistry, University Hospital of the RWTH Aachen, Pauwelstrasse 30, D-52074 Aachen, Germany. |
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| Abstract: | alpha-Synuclein aggregation into fibrils is associated with the pathogenesis of Parkinson's disease (PD). Li et al. provide strong evidence that rifampicin interacts with alpha-synuclein and inhibits its fibrillization. Rifampicin could be a promising candidate for therapeutic application for PD. |
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