Plasma fingerprinting with GC-MS in acute coronary syndrome |
| |
Authors: | M Vallejo A García J Tuñón D García-Martínez S Angulo JL Martin-Ventura L M Blanco-Colio P Almeida J Egido C Barbas |
| |
Institution: | (1) Pharmacy Faculty, San Pablo-CEU University Madrid, Campus Montepríncipe, Boadilla del Monte, 28668 Madrid, Spain;(2) Cardiology Service, Fundación Jiménez Díaz, Madrid, Spain;(3) Vascular Research Laboratory, Fundación Jiménez Díaz, Madrid, Spain;(4) Autónoma University, Madrid, Spain |
| |
Abstract: | New biomarkers of cardiovascular disease are needed to augment the information obtained from traditional indicators and to
illuminate disease mechanisms. One of the approaches used in metabolomics/metabonomics for that purpose is metabolic fingerprinting
aiming to profile large numbers of chemically diverse metabolites in an essentially nonselective way. In this study, gas chromatography-mass
spectrometry was employed to evaluate the major metabolic changes in low molecular weight plasma metabolites of patients with
acute coronary syndrome (n = 9) and with stable atherosclerosis (n = 10) vs healthy subjects without significant differences in age and sex (n = 10). Reproducible differences between cases and controls were obtained with pattern recognition techniques, and metabolites
accounting for higher weight in the classification have been identified through their mass spectra. On this basis, it seems
inherently plausible that even a simple metabolite profile might be able to offer improved clinical diagnosis and prognosis,
but in addition, specific markers are being identified. |
| |
Keywords: | Acute coronary syndrome Atherosclerosis Metabonomics Metabolomics Pattern recognition Separation techniques Stroke |
本文献已被 SpringerLink 等数据库收录! |
|