Cocrystal dissociation and molecular demixing in the solid state |
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Authors: | Mark D Eddleston Gareth O Lloyd William Jones |
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Affiliation: | Department of Chemistry, University of Cambridge, Cambridge, UK. mde32@cam.ac.uk |
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Abstract: | A new cocrystal containing caffeine and theophylline was found to dissociate on heating, with caffeine and theophylline molecules spontaneously demixing and recrystallizing as separate phases, in a solid-solid transition likely driven by an increase in entropy. The morphology and composition of the resulting crystals was determined by transmission electron microscopy. |
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