Identification of microcystin-RR and [Dha7]microcystin-RR in commercial standards by electrospray ionization mass spectrometry |
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Authors: | Kubwabo Cariton Vais Natalia Benoit Frank M |
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Institution: | Health Canada, Safe Environments Programme, Chemistry Research Division, Environmental Health Centre, PL, Tunney's Pasture, Ottawa, Ontario, Canada. Cariton_kubwabo@hc-sc.gc.ca |
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Abstract: | Three different commercial standards of microcystin-RR were assessed for purity by the liquid chromatography coupled with electrospray ionization mass spectrometry (LC/ESI/MS) technique. Although the liquid chromatograms with photodiode array detector for each standard looked virtually identical, the analysis of corresponding mass spectra revealed that only one of them contained microcystin-RR per purity assay. The second standard was a mixture of microcystin-RR, and its demethyl variant identified as Dha7]microcystin-RR, and the third one contained Dha7]microcystin-RR only. We strongly recommend applying LC coupled with MS for purity assay of microcystin standards. |
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