The Synthesis of Magnetic and Fluorescent Bi-functional Silica Composite Nanoparticles via Reverse Microemulsion Method |
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Authors: | Guannan Wang Chao Wang Wenchao Dou Qiang Ma Pingfan Yuan Xingguang Su |
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Institution: | (1) Department of Analytical Chemistry, College of Chemistry, Jilin University, Changchun, 130012, China; |
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Abstract: | In this paper, a simple synthesis method of small-size( about 50 nm in diameter), high magnetic and fluorescent bi-functional
silica composite nanoparticles were developed, in which water-soluble Fe3O4 magnetic nanoparticlels (MNs) and CdTe quantum dots (QDs) were directly incorporated into a silica shell by reverse microemulsion
method. The high luminescent QDs can be used as luminescent marker, while the high magnetic MNs allow the manipulation of
the bi-functional silica composite nanoparticles by external magnetic field. Poly (dimethyldiallyl ammonium chloride) was
used to balance the electrostatic repulsion between CdTe QDs and silica intermediates to enhance the fluorescence intensity
of MNs-QDs/SiO2 composite nanoparticles. The optical property, magnetic property, size characterization of the bi-functional composite nanoparticles
were studied by UV-Vis and PL emission spectra, VSM, TEM, SEM. The stabilities toward time, pH and ionic strength and the
effect of MNs on the fluorescence properties of bi-functional silica composite nanoparticles were also studied in detail.
By modifying the surface of MNs-QDs/SiO2 composite nanoparticles with amino and methylphosphonate groups, biologically functionalized and monodisperse MNs-QDs/SiO2composite nanoparticles can be obtained. In this work, bi-functional composite nanoparticles were conjugated with FITC labeled
goat anti-rabbit IgG, to generate novel fluorescent-magnetic-biotargeting tri-functional composite nanoparticles, which can
be used in a number of biomedical application. |
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