The rheologic properties of erythrocytes: a study using an automated rheoscope |
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Authors: | Bransky Avishay Korin Natanel Leshansky Alexander Lanir Naomi Nemirovski Yael Dinnar Uri |
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Institution: | (1) Biomedical Engineering, Technion, Haifa, 32000, Israel;(2) Chemical Engineering, Technion, Haifa, 32000, Israel;(3) Laboratory of Hematology, Rambam Medical Center, Haifa, 31096, Israel;(4) Electrical Engineering, Technion, Haifa, 32000, Israel |
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Abstract: | Red blood cells (RBCs) suspended in a high-viscosity medium were filmed while flowing through a microchannel using an automated
rheoscope. Under these conditions, erythrocytes take different orientations and undergo varying deformation according to their
location in the velocity profile. Measurements of the mean deformation at several distances from the center of the microchannel
at a constant flow rate were acquired for normal and thalassemia erythrocytes. The measurements demonstrate how diagnosis
can be made based on a single flow rate in contrast to conventional methods where shear is mechanically controlled. The spatial
distribution and velocity of RBCs and rigid microspheres (1 μm) were measured. The maximum slip velocity was found to be linearly
correlated to the flow rate for both cells and microspheres. RBCs showed enhanced inward lateral migration compared to the
rigid spheres, which is attributed to RBC deformation. The results demonstrate the coupling between RBC mechanical properties
and their motion in microvessels.
This paper was presented at Annual European Rheology Conference (AERC) held in Hersonisos, Crete, Greece, April 27-29, 2006. |
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Keywords: | RBC Lateral migration Erythrocytes Microchannel Rheoscope |
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