Fluorine-containing pyrido[1,2-a]quinazolin-6-ones |
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| Authors: | E. V. Nosova G. N. Lipunova M. I. Kodess P. V. Vasil’eva V. N. Charushin |
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| Affiliation: | (1) Ural State Technical University, 19 ul. Mira, 620002 Ekaterinburg, Russian Federation;(2) I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences, 20/22 ul. S. Kovalevskoi, 620219 Ekaterinburg, Russian Federation |
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| Abstract: | Reactions of 2-aminopyridine and 2-amino-5-methylpyridine with 2,3,4,5-tetrafluorobenzoyl chloride afforded N,N’-diaroylpyridinium salts, which were converted into 6H-pyrido[1,2-a]quinazolin-6-ones by refluxing in toluene in the presence of triethylamine. The angular structure of the tricyclic derivatives obtained was confirmed by 19F and 13C NMR spectroscopy and 2D heteronuclear HetCOR and HMBC experiments.__________Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 2216–2220, October, 2004. |
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| Keywords: | 2-aminopyridine 2,3,4,5-tetrafluorobenzoyl chloride pyrido[1,2-a]quinazolin-6-ones aroylation aminodefluorination |
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