| 间硝基苯甲醛或间氯苯甲醛与芳香胺和芳香酮的Mannich反应 |
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| 引用本文： | 邹君华.间硝基苯甲醛或间氯苯甲醛与芳香胺和芳香酮的Mannich反应[J].有机化学,1996,16(3):218-222. |
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| 作者姓名： | 邹君华 |
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| 作者单位： | 西南师范大学化学化工学院 四川，重庆 630715 |
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| 摘 要： | 间硝基苯甲醛或间氯苯甲醛与芳香胺和芳香酮在20~25℃和催化量的浓盐酸催化下能直接进行Mannich反应, 用一步合成法合成15个1-芳基-3-芳胺基(3-硝基苯基)丙酮。产率为68~87%。产物结构经元素分析, IR, ^1H NMR, MS鉴定。本文还讨论了反应的适宜条件。
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| 关 键 词： | 红外分光光度法 盐酸 质子磁共振谱法 曼尼希反应 芳香胺 间硝基苯甲醛 间氯苯甲醛 芳香酮 |
The Mannich reaction between 3-nitrobenzaldehyde (3-chlorobenzaldehyde), aromatic amines and aromatic ketones |
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| ZOU Jun-Hua.The Mannich reaction between 3-nitrobenzaldehyde (3-chlorobenzaldehyde), aromatic amines and aromatic ketones[J].Chinese Journal of Organic Chemistry,1996,16(3):218-222. |
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| Authors: | ZOU Jun-Hua |
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| Abstract: | In the presence of catalytic amount of hydrochloric acid, the Mannich reaction of 3-nitrobenzaldehyde (3-Chlorobenzaldehyde), aromatic amines and aromatic ketones can take place directly at 20~25℃. Fifteen corresponding Mannich bases (1a~1o), 1-aryl-3- arylamino 3-nitro(chloro) phenyl] acetone, were prepared with 68~87% yield. Some compounds were verified by elemental analysis, IR, ^1H NMR, MS. The reaction conditions were also discussed in this paper. |
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| Keywords: | Mannich reaction Mannich bases 3-nitrobenzaldehyde 3-chlorobenzaldehyde aromatic amines aromatic ketones |
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