聚集诱导发光分子在微生物检测和抗菌治疗中的应用

微生物检测和抗菌治疗与人类健康息息相关,快速检测和有效清除病原微生物对疾病治疗至关重要。传统的微生物检测方法如酶联免疫吸附检测（ELISA）、聚合酶链式反应（PCR）技术等,通常操作步骤复杂、耗时长且对仪器要求较高。另一方面,耐药性微生物的出现使得新型抗菌疗法的研发成为亟待解决的问题。聚集诱导发光分子（AIEgens）由于其出色的荧光和光敏性能,在微生物检测和抗菌治疗中表现出巨大的应用潜力。本文对AIEgens在微生物检测中的应用进行简要综述,总结了基于AIEgens的光动力治疗（photodynamic therapy, PDT）在细菌感染和多重耐药性细菌的清除中的应用研究,并对存在的不足以及未来的发展前景进行了讨论和展望。

Application of Aggregation-induced Emission Luminogens in Microbial Detection and Antibacterial Therapy

The microbial detection and antimicrobial therapy are closely related to human health. Rapid detection and efficient removal of pathogenic microorganisms are essential for disease treatment. Traditional microbial detection methods, such as enzyme-linked immunosorbent assay, polymerase chain reaction, etc., are generally limited by instrumental dependence, time-consuming and complexity in operation. On the other hand, the emergence of antibiotic-resistant pathogens makes the development of new antibacterial therapies an urgent problem to be solved. Aggregation-induced emission luminogens (AIEgens) have shown great potential in microbial detection and antibacterial therapy due to their excellent fluorescence and photosensitivity. Here, we briefly review the research progress of AIEgens in microbial detection, and summarizes the application of AIEgens-based photodynamic therapy (PDT) in the elimination of multidrug-resistant bacteria. Additionally, the shortcomings and perspectives for the future are discussed and concluded.