Diffuse reflectance spectroscopy with a self-calibrating fiber optic probe |
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Authors: | Yu Bing Fu Henry Bydlon Torre Bender Janelle E Ramanujam Nirmala |
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Institution: | Department of Biomedical Engineering, Duke University, Durham, NC 27705, USA. bing.yu@duke.edu |
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Abstract: | Calibration of the diffuse reflectance spectrum for instrument response and time-dependent fluctuation as well as interdevice variations is complicated, time consuming, and potentially inaccurate. We describe a novel fiber optic probe with a real-time self-calibration capability that can be used for tissue optical spectroscopy. The probe was tested in a number of liquid phantoms over a relevant range of tissue optical properties. Absorption and scattering coefficients are extracted with an average absolute error and standard deviation of 6.9%+/-7.2% and 3.5%+/-1.5%, respectively. |
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