Continuous Flow Synthesis of Propofol |
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| Authors: | Romain Mougeot Philippe Jubault Julien Legros Thomas Poisson |
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| Institution: | 1.CNRS, INSA Rouen, UNIROUEN, Normandie University, COBRA, 76000 Rouen, France;2.Institut Universitaire de France, 1 Rue Descartes, 75231 Paris, France |
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| Abstract: | Herein, we report a continuous flow process for the synthesis of 2,6-diisopropylphenol—also known as Propofol—a short-acting intravenous anesthesia, widely used in intensive care medicine to provide sedation and hypnosis. The synthesis is based on a two-step procedure: a double Friedel–Crafts alkylation followed by a decarboxylation step, both under continuous flow. |
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| Keywords: | active pharmaceutical ingredient anesthetics Friedel– Crafts decarboxylation |
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