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Monitoring Methylmalonic Aciduria by NMR Urinomics |
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| Authors: | Alina Nicolescu Daniela Blanita Chiril Boiciuc Victoria Hlistun Mihaela Cristea Dorina Rotaru Ludmila Pinzari Ana Oglinda Adela Stamati Isabela Tarcomnicu Andreea Tutulan-Cunita Danae Stambouli Sergiu Gladun Ninel Revenco Natalia Uurelu Calin Deleanu |
| Abstract: | The paper reports on monitoring methylmalonic aciduria (MMA)-specific and non-specific metabolites via NMR urinomics. Five patients have been monitored over periods of time; things involved were diet, medication and occasional episodes of failing to comply with prescribed diets. An extended dataset of targeted metabolites is presented, and correlations with the type of MMA are underlined. A survey of previous NMR studies on MMA is also presented. |
| Keywords: | methylmalonic aciduria methylmalonic acid NMR spectroscopy urine metabolomics |