Effects of Sucrose Palmitate on the Physico-Chemical and Mucoadhesive Properties of Buccal Films |
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| Authors: | Andrs Kelemen Blint Katona Szilvia Mdra Zoltn Aigner Istvn Sebe Klra Pintye-Hdi Romna Zelk Gza Regdon Jr Katalin Krist |
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| Institution: | 1.Department of Applied Informatics, University of Szeged, Boldogasszony sgt. 6., H-6725 Szeged, Hungary; ;2.Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eötvös u. 6., H-6720 Szeged, Hungary; (B.K.); (S.M.); (Z.A.); (K.P.-H.); (K.K.);3.University Pharmacy Department of Pharmacy Administration, Semmelweis University, Hőgyes E. u. 7-9., H-1092 Budapest, Hungary; (I.S.); (R.Z.) |
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| Abstract: | In our current research, sucrose palmitate (SP) was applied as a possible permeation enhancer for buccal use. This route of administration is a novelty as there is no literature on the use of SP in buccal mucoadhesive films. Films containing SP were prepared at different temperatures, with different concentrations of SP and different lengths of hydroxypropyl methylcellulose (HPMC) chains. The mechanical, structural, and in vitro mucoadhesive properties of films containing SP were investigated. Tensile strength and mucoadhesive force were measured with a device and software developed in our Institute. Positron annihilation lifetime spectroscopy (PALS) and X-ray powder diffractometry (XRPD) were applied for the structure analysis of the films. Mucoadhesive work was calculated in two ways: from the measured contact angle and compared with direct mucoadhesive work, which measured mucoadhesive force, which is direct mucoadhesion work. These results correlate linearly with a correlation coefficient of 0.98. It is also novel because it is a new method for the determination of mucoadhesive work. |
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| Keywords: | mucoadhesion buccal film mucoadhesive work sucrose-palmitate |
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