Synthesis and Dynamic NMR Studies of Some New Symmetrical Podands of Dithiocarbamates Formed from Bis(N‐thiazol)chloroacetamides

Reactions of dithiocarbamates salts ( IVa , IVb , IVc ) with bis(N‐thiazol) chloroacetamides( IIa , IIb ) in DMF furnished corresponding podands as Va , Vb , Vc , Vd , Ve , Vf in high to excellent yields. Two reacting ligands ( IIa , IIb ) were obtained in the reaction of bis(aminothiazoles) ( Ia , Ib ) with chloroacetyl chloride. Dynamic NMR spectroscopic data of two series of podands ( Va , Vb , Vc and Vd , Ve , Vf ) are discussed and figured out their free energy of activation () at coalescence temperatures. The s of these podands were attributed to conformational isomerization in the range of 14.9–16.2 kcal/mol due to rotation and resonance effect about thioamide C―N bond.