17a-acetoxy-16,16-dimethyl-8-aza-D-homogona-1,3,5(10),9(11),13,17-hexaen-12-one, the product of acylotropic rearrangement at interaction of 16,16-dimethyl-8-aza-D-homogona-1,3,5(10),9(11),13-pentaene-12,17a-dione with acetic anthydride

On interaction of 16,16-dimethyl-8-aza-D-homogona-1,3,5(10),9(11),13-pentaene-12, 17a-dione with acetic anhydride acylotropic rearrangement occurs with the formation of a single product, viz. 17a-acetoxy-16, 16-dimethyl-8-aza-D-homogona-1,3,5(10),9(11),-13, 17a-hexaen-12-one. The effect of sodium acetate and of acetic acid concentration on the result of the reaction has been studied. The structure of the product was confirmed by data of elemental analysis, IR, UV,¹H, and¹³C NMR spectroscopy, mass spectrometry, and also X-ray structural analysis. Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk 220141. Scientific Research Institute of Physicochemical Problems, Belarussian State University, Minsk 220080. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1376–1387, October, 1999.