A novel daphnane-type diterpene from the flower bud of <Emphasis Type="Italic">Daphne genkwa</Emphasis> |
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| Authors: | L Z Li P Y Gao Y Peng L H Wang S J Song |
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| Institution: | 1.School of Traditional Chinese Materia Medica,Key Laboratory of Structure-Based Drug Desig n & Discovery (Shenyang Pharmaceutical University), Ministry of Education,Shenyang,China;2.School of Pharmacy,Shenyang Pharmaceutical University,Shenyang,China |
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| Abstract: | A novel daphnane-type diterpene, genkwanin I (1), and a novel natural product, orthobenzoate 2 (2), were isolated from the flower bud of Daphne genkwa. The structures of the two compounds were elucidated by spectral techniques, viz.1D, 2D NMR spectra and HR-ESI-MS. Genkwanin
I showed inhibitory activity against human promyelocytic HL-60 cells at an IC50 level of 11.74 μM. |
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