| 一个异常的吡啶环的酰化反应 |
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| 引用本文： | 邱惊雷,广兵,彭向阳,张志业.一个异常的吡啶环的酰化反应[J].化学研究,2007,18(2):38-39. |
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| 作者姓名： | 邱惊雷 广兵 彭向阳 张志业 |
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| 作者单位： | 四川大学,化工学院,四川,成都,610065 |
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| 摘 要： | 吡啶环作为一种缺π电子的芳杂环,其酰化反应一般需要在较强烈的反应条件下才能进行,且酰化主要发生在β位上.本文报道了一个温和条件下发生的吡啶环α位上的酰化反应,即在室温下,将3,5,6-三甲基-2-吡嗪甲酸(川芎酸)加入到三氯氧磷和吡啶的混合物中,迅速发生反应,产物经MS,IR,1HNMR,13CNMR等谱图表征,为吡啶的α位酰化物.
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| 关 键 词： | 吡啶环 酰化反应 3 5 6-三甲基-2-吡嗪甲酸 α位 |
| 文章编号： | 1008-1011（2007）02-0038-02 |
| 修稿时间： | 2006-12-16 |
A Novel Acylating Reaction for Pyridine |
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| QIU Jing-lei,GUANG Bing,PENG Xiang-yang,ZHANG Zhi-ye.A Novel Acylating Reaction for Pyridine[J].Chemical Research,2007,18(2):38-39. |
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| Authors: | QIU Jing-lei GUANG Bing PENG Xiang-yang ZHANG Zhi-ye |
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| Institution: | School of Chemical Engineering, Sichuan University, Chengdu 610065, Sichuan, China |
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| Abstract: | The acylating reactions occuring at β-position of pyridine are usually conducted in harsh conditions. In this paper we reported an unusual acylating reaction at α-position of pyridine which happened smoothly in a mild condition.The mixture of phosphorus oxychloride and pyridine was treated with 3,5,6-trimethyl-2-pyrazinecarboxylic acid resulting in an acylating product which is proved to be 2-pyridinoyl-3,5,6-trimethylpyrazine through the analysis of MS,IR,1H NMR and 13C NMR. |
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| Keywords: | pyridine acylating reaction 3 5 6-trimethyl-2-pyrazinecarboxylic acid α-position |
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