Total synthesis of a conformationally constrained didemnin B analog |
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| Authors: | Xiao D Vera M D Liang B Joullié M M |
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| Institution: | Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104-6323, USA. |
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| Abstract: | The total synthesis of a didemnin B analogue containing a conformationally constrained replacement for the isostatine moiety is reported. Synthetic highlights include an improved preparation of 2-hydroxy-3-cyclohexenecarboxylic acid and a new strategy for accessing the macrocycle. |
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