Raman Spectroscopy and Fluorescence Photon Migration for Breast Cancer Diagnosis and Imaging |
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| Authors: | Ramasamy Manoharan Karen Shafer Lev Perelman Jun Wu Kun Chen Geurt Deinum Maryann Fitzmaurice Jonathan Myles Joseph Crowe Ramachandra R Dasarl Michael S Feld |
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| Institution: | George R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA;University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH, USA;Department of Pathology, Cleveland Clinic Foundation, Cleveland, OH, USA;Department of Surgical Oncology, Cleveland Clinic Foundation, Cleveland, OH, USA |
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| Abstract: | We are developing optical methods based on near infra-red Raman spectroscopy and fluorescence photon migration for diagnosis and localization of breast cancer. We demonstrate the ability of Raman spectroscopy to classify accurately normal, benign and malignant breast tissues, an important step in developing Raman spectroscopic needle probes as a tool for improving the accuracy of needle biopsy. We also show that photon migration imaging can be used to localize accurately small fluorescent objects imbedded in a thick turbid medium with realistic optical properties, thus demonstrating the potential of this technique for optical imaging. |
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