Novel beta-lactam antibiotics synthesized by amination of catechols using fungal laccase |
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| Authors: | Mikolasch Annett Wurster Martina Lalk Michael Witt Sabine Seefeldt Simone Hammer Elke Schauer Frieder Jülich Wolf-Dieter Lindequist Ulrike |
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| Institution: | Institute of Microbiology, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany. annett.mikolasch@gmx.de |
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| Abstract: | Novel cephalosporins, penicillins, and carbacephems were synthesized by amination of catechols with amino-beta-lactams like cefadroxil, amoxicillin, ampicillin and the structurally related carbacephem loracarbef using laccase from Trametes sp. All isolated monoaminated products inhibited the growth of several Gram positive bacterial strains in the agar diffusion assay, among them methicillin-resistant Staphylococcus aureus strains and vancomycin-resistant Enterococci. Observed differences in the cytotoxicity and in vivo activity in a "Staphylococcus-infected, immune suppressed mouse" model are discussed. |
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