Influence of bilirubin on the distribution of99mTc-HIDA and99mTc-IODIDA in rats and their interaction with HSA |
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| Authors: | M S Jovanovic B Zmbova D Zivanov-Stakic S Vladimirov |
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| Institution: | (1) The Institute of Nuclear Sciences, P.O. Box 522, 11001 Belgrade, (Yugoslavia);(2) The Faculty of Pharmacy, Belgrade, (Yugoslavia) |
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| Abstract: | The interaction of bilirubin and99mTc-HIDA and99mTc-IODIDA has been studied in rats. The mechanism of this interaction has been examined at the level of binding with human serum albumin (HSA) by the in vitro method. Percentage of binding with HSA, and affinity constants for99mTc-IODIDA were determined with and without bilirubin. Bilirubin was labeled with99mTc and its interaction with HSA was also examined. |
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